FOXO4-DRI vs Epitalon: Senolytic and Aging Research Comparison

FOXO4-DRI and Epitalon represent two fundamentally different approaches to aging research. FOXO4-DRI is a D-retro-inverso senolytic peptide that selectively eliminates senescent cells by disrupting the FOXO4-p53 interaction. Epitalon is a synthetic tetrapeptide that activates telomerase reverse transcriptase (hTERT) to maintain telomere length. Researchers compare these to choose between senescent cell clearance and telomere maintenance strategies.