Semaglutide (10mg)

Semaglutide is a modified glucagon-like peptide-1 (GLP-1) receptor agonist consisting of 31 amino acids with strategic modifications at positions 8 (Aib substitution) and 26 (C-18 fatty diacid acylation via a linker) that confer extended stability and a plasma half-life of approximately 165 hours. Its molecular weight is approximately 4,113 Da.

Semaglutide is among the most extensively studied peptides in metabolic research. Clinical investigations have examined its binding affinity for the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the gastrointestinal tract, and central nervous system regions involved in appetite regulation. Research has documented its effects on glucose-dependent insulin secretion, glucagon suppression, and gastric emptying kinetics. Preclinical and clinical studies have also investigated its interactions with hypothalamic appetite circuits and potential neuroprotective properties.

The mechanism of action involves high-affinity GLP-1R binding, triggering cAMP-dependent signaling cascades that modulate insulin granule exocytosis, beta-cell gene transcription, and central satiety signaling via vagal afferent and hypothalamic pathways.

Viking Labs provides research-grade semaglutide synthesized at a USA-based cGMP facility. Each batch is independently verified at 99%+ purity via HPLC analysis. Certificate of Analysis included with every order. All vials are batch serialized and sterile filled under aseptic conditions.

Storage: Store lyophilized peptide at -20C. Reconstituted solution at 2-8C, stable for up to 30 days. Protect from light and avoid freeze-thaw cycles.

For laboratory research use only. Not for human consumption.